A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries
Name
A peptide for targeted.pdf
Size
2.86 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Mann, Aman P.
Scodeller, Pablo
Hussain, Sazid
Joo, Jinmyoung
Braun, Gary B.
Mölder, Tarmo
She, Zhi-Gang
Kotamraju, Venkata Ramana
Ranscht, Barbara
Krajewski, Stan
Date Issued
June 2016
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Mann, Aman P. et al. “A Peptide for Targeted, Systemic Delivery of Imaging and Therapeutic Compounds into Acute Brain Injuries.” Nature Communications 7 (2016): 11980. © 2017 Macmillan Publishers Limited
Version
Final published version
Abstract
Traumatic brain injury (TBI) is a major health and socio-economic problem, but no pharmacological agent is currently approved for the treatment of acute TBI. Thus, there is a great need for advances in this field. Here, we describe a short peptide (sequence CAQK) identified by in vivo phage display screening in mice with acute brain injury. The CAQK peptide selectively binds to injured mouse and human brain, and systemically injected CAQK specifically homes to sites of brain injury in mouse models. The CAQK target is a proteoglycan complex upregulated in brain injuries. Coupling to CAQK increased injury site accumulation of systemically administered molecules ranging from a drug-sized molecule to nanoparticles. CAQK-coated nanoparticles containing silencing oligonucleotides provided the first evidence of gene silencing in injured brain parenchyma by systemically administered siRNA. These findings present an effective targeting strategy for the delivery of therapeutics in clinical management of acute brain injuries.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution 4.0 International License
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DOI of Published Version
https://doi.org/10.1038/ncomms11980
