Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging of General Anesthesia
Name
Brown-Simultaneous Electroencephalography.pdf
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989.39 KB
Format
Adobe PDF
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Author(s)
Purdon, Patrick Lee
Pierce, Eric T.
Bonmassar, Giorgio
Walsh, John
Harrell, P. Grace
Kwo, Jean
Deschler, Daniel
Barlow, Margaret
Merhar, Rebecca C.
Lamus Garcia Herreros, Camilo
Date Issued
March 2009
Journal
Annals of the New York Academy of Sciences
Publisher
John Wiley & Sons, Inc.
Citation
Purdon, Patrick L. et al. “Simultaneous Electroencephalography and Functional Magnetic Resonance Imaging of General Anesthesia.” Annals of the New York Academy of Sciences 1157.1 (2009): 61–70. Web.
Version
Author's final manuscript
Abstract
It has been long appreciated that anesthetic drugs induce stereotyped changes in electroencephalogram (EEG), but the relationships between the EEG and underlying brain function remain poorly understood. Functional imaging methods including positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), have become important tools for studying how anesthetic drugs act in the human brain to induce the state of general anesthesia. To date, no investigation has combined functional MRI with EEG to study general anesthesia. We report here a paradigm for conducting combined fMRI and EEG studies of human subjects under general anesthesia. We discuss the several technical and safety problems that must be solved to undertake this type of multimodal functional imaging and show combined recordings from a human subject. Combined fMRI and EEG exploits simultaneously the high spatial resolution of fMRI and the high temporal resolution of EEG. In addition, combined fMRI and EEG offers a direct way to relate established EEG patterns induced by general anesthesia to changes in neural activity in specific brain regions as measured by changes in fMRI blood oxygen level dependent (BOLD) signals.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1111/j.1749-6632.2008.04119.x
