Reservoir-based drug delivery systems utilizing microtechnology
Name
nihms360102.pdf
Description
Accepted version
Size
1.96 MB
Format
Unknown
Checksum (MD5)
82c44d48c4cdf45c6f9cf9459df91694
Author(s)
Stevenson, Cynthia L
Santini, John T.
Langer, Robert S
Date Issued
2012
Journal
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Citation
Stevenson, C. L., J. T. Santini Jr, and R. Langer. "Reservoir-Based Drug Delivery Systems Utilizing Microtechnology." Advanced Drug Delivery Reviews (2012).
Version
Author's final manuscript
Abstract
This review covers reservoir-based drug delivery systems that incorporate microtechnology, with an emphasis on oral, dermal, and implantable systems. Key features of each technology are highlighted such as working principles, fabrication methods, dimensional constraints, and performance criteria. Reservoir-based systems include a subset of microfabricated drug delivery systems and provide unique advantages. Reservoirs, whether external to the body or implanted, provide a well-controlled environment for a drug formulation, allowing increased drug stability and prolonged delivery times. Reservoir systems have the flexibility to accommodate various delivery schemes, including zero order, pulsatile, and on demand dosing, as opposed to a standard sustained release profile. Furthermore, the development of reservoir-based systems for targeted delivery for difficult to treat applications (e.g., ocular) has resulted in potential platforms for patient therapy. © 2012 Elsevier B.V.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.addr.2012.02.005
