Ruler arrays detect genomic insertions and deletions
Name
549290868-MIT.pdf
Description
Full printable version
Size
1.51 MB
Format
Adobe PDF
Checksum (MD5)
59d3637a71a6c565ae99e6a79899f3a0
Author(s)
Rolfe, P. Alexander (Philip Alexander), 1979-
Advisor(s)
David K. Gifford.
Date Issued
2009
Publisher
Massachusetts Institute of Technology
Abstract
A Ruler Array measures the distance between a set of microarray probes and a set of experimentally defined locations in a nucleic acid, offering new possibilities for locating and characterizing changes in the nucleic acid sequence. Despite the known relevance of genomic changes to pathogens, cancer, development, and evolution, many of these changes evade detection by existing high-throughput techniques. Since a microarray can interrogate thousands or millions of probes at once, Ruler Arrays can screen a small genome or part of a mammalian sized genome for insertions, deletions, and inversions in a single experiment.
Description
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student submitted PDF version of thesis.
Includes bibliographical references (p. 137-142).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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