Synthetic biology: Understanding biological design from synthetic circuits
Name
van Oudenaarden_Synthetic biology.pdf
Size
1.2 MB
Format
Adobe PDF
Checksum (MD5)
6d046b2c161ae3981f6a0cfeb6975926
Author(s)
Mukherji, Shankar
van Oudenaarden, Alexander
Date Issued
November 2009
Journal
Nature Reviews Genetics
Publisher
Nature Publishing Group
Citation
Mukherji, Shankar, and Alexander van Oudenaarden. “Synthetic Biology: Understanding Biological Design from Synthetic Circuits.” Nature Reviews Genetics (2009)
Version
Author's final manuscript
Abstract
An important aim of synthetic biology is to uncover the design principles of natural biological systems through the rational design of gene and protein circuits. Here, we highlight how the process of engineering biological systems — from synthetic promoters to the control of cell–cell interactions — has contributed to our understanding of how endogenous systems are put together and function. Synthetic biological devices allow us to grasp intuitively the ranges of behaviour generated by simple biological circuits, such as linear cascades and interlocking feedback loops, as well as to exert control over natural processes, such as gene expression and population dynamics.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1038/nrg2697
