Rac GTPases play multiple roles in erythropoiesis
Name
Lodish_Rac GTPases.pdf
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123.42 KB
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Author(s)
Ji, Peng
Lodish, Harvey F
Date Issued
January 2010
Journal
Haematologica
Publisher
Ferrata Storti Foundation
Citation
Ji, P., and H. F. Lodish. “Rac GTPases Play Multiple Roles in Erythropoiesis.” Haematologica 95.1 (2010): 2–4. Copyright © 2010 Ferrata Storti Foundation
Version
Final published version
Abstract
The four members of the Rac family of GTPases –Rac1, Rac2, Rac3 and RhoG – are members of the Rho superfamily that regulates the organization, dynamics, and function of the actin cytoskeleton. Rac GTPases play significant roles in many cellular processes including migration, cytokinesis, lamellipodia formation, and cell polarity.1 Genetically modified mice deficient in each of the Racs are available;2–6 deficiency of Rac1 causes intrauterine death, whereas mice defective in Rac2, Rac3 or RhoG develop fairly normally. Rac proteins may have redundant functions in certain types of cells and unique functions in others.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.3324/haematol.2009.015511
