Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea
Author(s)
Palace, Samantha G
Fryling, Kyra E
Li, Ying
Wentworth, Adam J
Traverso, Giovanni
Grad, Yonatan H
Date Issued
2021
Journal
Journal of Antimicrobial Chemotherapy
Publisher
Oxford University Press (OUP)
Citation
Palace, Samantha G, Fryling, Kyra E, Li, Ying, Wentworth, Adam J, Traverso, Giovanni et al. 2021. "Identification of bile acid and fatty acid species as candidate rapidly bactericidal agents for topical treatment of gonorrhoea." Journal of Antimicrobial Chemotherapy, 76 (10).
Version
Author's final manuscript
Abstract
Novel therapeutic strategies are urgently needed for Neisseria gonorrhoeae, given its increasing antimicrobial resistance. Treatment of oropharyngeal N. gonorrhoeae infections has proven particularly challenging, with most reported treatment failures of the first-line drug ceftriaxone occurring at this site and lower cure rates in recent trials of new antibiotics reported for oropharyngeal infections compared with other sites of infection. However, the accessibility of the oropharynx to topical therapeutics provides an opportunity for intervention. Local delivery of a therapeutic at a high concentration would enable the use of non-traditional antimicrobial candidates, including biological molecules that exploit underlying chemical sensitivities of N. gonorrhoeae but lack the potency or pharmacokinetic profiles required for effective systemic administration.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1093/JAC/DKAB217
