Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration
Name
Tsai-Linking Cell Cycle.pdf
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133.85 KB
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Author(s)
Kim, Dohoon
Tsai, Li-Huei
Date Issued
August 2009
Journal
Annals of the New York Academy of Sciences
Publisher
New York Academy of Sciences
Citation
Kim, Dohoon, and Li-Huei Tsai. “Linking Cell Cycle Reentry and DNA Damage in Neurodegeneration.” Annals of the New York Academy of Sciences 1170 (2009): 674-679. Web. 1 Dec. 2011. © 2009 New York Academy of Sciences
Version
Final published version
Abstract
Aberrant cell cycle activity and DNA damage have been observed in neurons in association with various neurodegenerative conditions. While there is strong evidence for a causative role for these events in neurotoxicity, it is unclear how they are triggered and why they are toxic. Here, we introduce a brief background of the current view on cell cycle activity and DNA damage in neurons and speculate on their relevance to neuronal survival. Furthermore, we suggest that the two events may be triggered in common by deregulation of fundamental processes, such as chromatin modulation, which are required for maintaining both DNA integrity and proper regulation of cell cycle gene expression.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1111/j.1749-6632.2009.04105.x
