Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography
Name
Choma-2010-Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography.pdf
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Author(s)
Choma, Michael A.
Suter, Melissa J.
Vakoc, Benjamin
Bouma, Brett E.
Tearney, Guillermo J.
Date Issued
September 2010
Journal
Journal of Biomedical Optics
Publisher
Society of Photo-optical Instrumentation Engineers
Citation
Choma, Michael A. et al. “Heart Wall Velocimetry and Exogenous Contrast-based Cardiac Flow Imaging in Drosophila Melanogaster Using Doppler Optical Coherence Tomography.” Journal of Biomedical Optics 15.5 (2010) : 056020-6. © 2010 SPIE.
Version
Final published version
Abstract
Drosophila melanogaster (fruit fly) is a central organism in biology and is becoming increasingly important in the cardiovascular sciences. Prior work in optical imaging of the D. melanogaster heart has focused on static and dynamic structural anatomy. In the study, it is demonstrated that Doppler optical coherence tomography can quantify dynamic heart wall velocity and hemolymph flow in adult D. melanogaster. Since hemolymph is optically transparent, a novel exogenous contrast technique is demonstrated to increase the backscatter-based intracardiac Doppler flow signal. The results presented here open up new possibilities for functional cardiovascular phenotyping of normal and mutant D. melanogaster.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/1.3503418
