Polymers for extended-release administration
Name
10544_2019_386_ReferencePDF.pdf
Size
1.56 MB
Format
Adobe PDF
Checksum (MD5)
dbb31813547e6062ddbfbe92f0f0d3c0
Author(s)
Paolini, Marion
Fenton, Owen Shea
Bhattacharya, Chandrabali
Andresen, Jason
Langer, Robert S
Date Issued
April 2019
Journal
Biomedical Microdevices
Publisher
Springer Science and Business Media LLC
Citation
Paolini, Marion S. et al. "Polymers for extended-release administration." Biomedical Microdevices 21, 2 (April 2019): 45 © 2019 Springer Science Business Media, LLC
Version
Author's final manuscript
Abstract
Developing strategies to deliver the required dose of therapeutics into target tissues and cell populations within the body is a principal aim of controlled release and drug delivery. Specifically, there is an interest in developing formulations that can achieve drug concentrations within the therapeutic window, for extended periods of time, with tunable release profiles, and with minimal complication and distress for the patient. To date, drug delivery systems have been developed to serve as depots, triggers, and carriers for therapeutics including small molecules, biologics, and cell-based therapies. Notably, the efficacy of these systems is intricately tied to the manner in which they are administered. For example, systemic and oral routes of administration are common, but both can result in rapid clearance from the organism. Towards this end, what formulation and administration route strategies are available to prolong the bioavailability of therapeutics? Here, we discuss historical and modern drug delivery systems, with the intention of exploring how properties including formulation, administration route and chemical structure influence the ability to achieve extended-release drug release profiles within the body.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1007/s10544-019-0386-9
