Vertical hydrodynamic focusing in an isotropically etched glass microfluidic device
Name
182540246-MIT.pdf
Description
Full printable version
Size
15.58 MB
Format
Adobe PDF
Checksum (MD5)
c5cb4f5fb73ee78dc479556509280ebf
Author(s)
Lin, Tony An-tong
Advisor(s)
Daniel E. Ehrlich and Anette Hosoi.
Date Issued
2007
Publisher
Massachusetts Institute of Technology
Abstract
The development of microfluidic devices has enabled precision control of nanoliter-scale environments and reactions. Vertical hydrodynamic focusing is one possible way to improve the optical performance of these devices while maintaining precision control. Vertical hydrodynamic focusing was studied through the use of computation fluid dynamics (ADINA) and experimental testing. It was found that the nonlinear effects of flow rate and geometry on the layering profile could be used to tune and correct the flow. A syringe pump-driven microfluidic device was fabricated out of isotropically etched and bonded glass plates and fluorescent confocal microscopy was used to verify computational models.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.
Includes bibliographical references (p. 107-109).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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