Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization
Name
i1552-5783-63-1-20_1642157993.24216.pdf
Description
Published version
Size
2.18 MB
Format
Adobe PDF
Checksum (MD5)
0253eb20bf8ab6dbc403aa6c93fdb2d7
Author(s)
Trivizki, Omer
Moult, Eric M
Wang, Liang
Iyer, Prashanth
Shi, Yingying
Gregori, Giovanni
Feuer, William
Fujimoto, James G
Rosenfeld, Philip J
Date Issued
January 14, 2022
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Citation
Omer Trivizki, Eric M. Moult, Liang Wang, Prashanth Iyer, Yingying Shi, Giovanni Gregori, William Feuer, James G. Fujimoto, Philip J. Rosenfeld; Local Geographic Atrophy Growth Rates Not Influenced by Close Proximity to Non-Exudative Type 1 Macular Neovascularization. Invest. Ophthalmol. Vis. Sci. 2022;63(1):20.
Version
Final published version
Abstract
Purpose: The local growth rates of geographic atrophy (GA) adjacent to non-exudative type 1 macular neovascularization (MNV) were investigated to determine if MNV influenced GA growth.
Methods: Eyes with GA and non-exudative type 1 MNV were followed for at least 1 year. Both GA and the MNV were imaged and measured using swept-source optical coherence tomography angiography (SS-OCTA) scans. Pearson correlations were computed between local growth rates of GA, which were estimated using a biophysical GA growth model, and local distances-to-MNV. Corresponding P values for the null hypothesis of no Pearson correlation were computed using a Monte Carlo approach that adjusts for spatial autocorrelations.
Results: Nine eyes were included in this study. There were positive correlations (Pearson's r > 0) between distance-to-MNV and local GA growth in eight (89%) of the eyes; however, in all but one eye (11%), correlations were relatively weak and statistically nonsignificant after Bonferroni correction (corrected P > 0.05).
Conclusions: SS-OCTA imaging combined with GA growth modeling and spatial statistical analysis enabled quantitative assessment of correlations between local GA growth rates and local distances-to-MNV. Our results are not consistent with non-exudative type 1 MNV having a strong inhibitory effect on local GA growth rates.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivatives
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1167/iovs.63.1.20
