A rapidly deployable individualized system for augmenting ventilator capacity
Name
A_rapidly_deployable_individualized_system_for_aug.pdf
Description
Accepted version
Size
2.91 MB
Format
Adobe PDF
Checksum (MD5)
190cbf7aa3a218d5548f63e0f617f49f
Author(s)
Srinivasan, Shriya Sruthi
Ramadi, Khalil
Vicario, Francesco
Gwynne, Declan A
Hayward, Alison M
Lagier, David
Langer, Robert S
Frassica, Joseph J.
Baron, Rebecca M.
Traverso, Carlo Giovanni
Date Issued
May 2020
Journal
Science Translational Medicine
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Srinivasan, Shriya S. et al. "A rapidly deployable individualized system for augmenting ventilator capacity." Science Translational Medicine 12, 549 (May 2020): eabb9401. © 2020 The Authors
Version
Author's final manuscript
Abstract
Strategies to split ventilators to support multiple patients requiring ventilatory support have been proposed and used in emergency cases in which shortages of ventilators cannot otherwise be remedied by production or procurement strategies. However, the current approaches to ventilator sharing lack the ability to individualize ventilation to each patient, measure pulmonary mechanics, and accommodate rebalancing of the airflow when one patient improves or deteriorates, posing safety concerns to patients. Potential cross-contamination, lack of alarms, insufficient monitoring, and inability to adapt to sudden changes in patient status have prevented widespread acceptance of ventilator sharing. We have developed an individualized system for augmenting ventilator efficacy (iSAVE) as a rapidly deployable platform that uses a single ventilator to simultaneously and more safely support two individuals. The iSAVE enables individual-specific volume and pressure control and the rebalancing of ventilation in response to improvement or deterioration in an individual's respiratory status. The iSAVE incorporates mechanisms to measure pulmonary mechanics, mitigate cross-contamination and backflow, and accommodate sudden flow changes due to individual interdependencies within the respiratory circuit. We demonstrate these capacities through validation using closed- and open-circuit ventilators on linear test lungs. We show that the iSAVE can temporarily ventilate two pigs on one ventilator as efficaciously as each pig on its own ventilator. By leveraging off-the-shelf medical components, the iSAVE could rapidly expand the ventilation capacity of health care facilities during emergency situations such as pandemics.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1126/scitranslmed.abb9401
