Effect of Terminal Modification on the Molecular Assembly and Mechanical Properties of Protein-Based Block Copolymers
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nihms905373.pdf
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Author(s)
Jacobsen, Matthew M.
Huang, Wenwen
Li, David
Simon, Marc
Staii, Cristian
Tokareva, Olena
Ebrahimi, Davoud
Ling, Shengjie
Dinjaski, Nina
Buehler, Markus J
Date Issued
June 2017
Journal
Macromolecular Bioscience
Publisher
Wiley
Citation
Jacobsen, Matthew M., Olena S. Tokareva, Davoud Ebrahimi, Wenwen Huang, Shengjie Ling, Nina Dinjaski, David Li, et al. “Effect of Terminal Modification on the Molecular Assembly and Mechanical Properties of Protein-Based Block Copolymers.” Macromolecular Bioscience 17, no. 9 (June 30, 2017): 1700095.
Version
Author's final manuscript
Abstract
Accurate prediction and validation of the assembly of bioinspired peptide sequences into fibers with defined mechanical characteristics would aid significantly in designing and creating materials with desired properties. This process may also be utilized to provide insight into how the molecular architecture of many natural protein fibers is assembled. In this work, computational modeling and experimentation are used in tandem to determine how peptide terminal modification affects a fiber-forming core domain. Modeling shows that increased terminal molecular weight and hydrophilicity improve peptide chain alignment under shearing conditions and promote consolidation of semicrystalline domains. Mechanical analysis shows acute improvements to strength and elasticity, but significantly reduced extensibility and overall toughness. These results highlight an important entropic function that terminal domains of fiber-forming peptides exhibit as chain alignment promoters, which ultimately has notable consequences on the mechanical behavior of the final fiber products.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Department of Physics
MIT Kavli Institute for Astrophysics and Space Research
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/MABI.201700095
