A Cholinergic Mechanism for Reward Timing within Primary Visual Cortex
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Bear_Cholinergic mechanism.pdf
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Author(s)
Chubykin, Alexander A.
Roach, Emma B.
Shuler, Marshall G. Hussain
Bear, Mark
Chubykin, Alexander A.
Date Issued
February 2013
Journal
Neuron
Publisher
Elsevier
Citation
Chubykin, Alexander A., Emma B. Roach, Mark F. Bear, and Marshall G. Hussain Shuler. “A Cholinergic Mechanism for Reward Timing Within Primary Visual Cortex.” Neuron 77, no. 4 (February 2013): 723–735.
Version
Author's final manuscript
Abstract
Neurons in rodent primary visual cortex (V1) relate operantly conditioned stimulus-reward intervals with modulated patterns of spiking output, but little is known about the locus or mechanism of this plasticity. Here we show that cholinergic basal forebrain projections to V1 are necessary for the neural acquisition, but not the expression, of reward timing in the visual cortex of awake, behaving animals. We then mimic reward timing in vitro by pairing white matter stimulation with muscarinic receptor activation at a fixed interval and show that this protocol results in the prolongation of electrically evoked spike train durations out to the conditioned interval. Together, these data suggest that V1 possesses the circuitry and plasticity to support reward time prediction learning and the cholinergic system serves as an important reinforcement signal which, in vivo, conveys to the cortex the outcome of behavior.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2012.12.039
