Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility
Name
nihms-228311.pdf
Description
Accepted version
Size
3.68 MB
Format
Adobe PDF
Checksum (MD5)
9d4dcdc56d7ee5fd3f70a2b6b227dfd3
Author(s)
Bruggeman, Joost P.
Bettinger, Christopher J.
Langer, Robert
Date Issued
August 2010
Journal
Journal of Biomedical Materials Research
Publisher
Wiley-Blackwell
Citation
Bruggeman, Joost P., Bettingera, Christopher J. and Langera, Robert. "Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility." Journal of Biomedical Materials Research 95A, 1 (October 2010): 92-104 © 2010 Wiley Periodicals.
Version
Author's final manuscript
Abstract
Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants. Keywords: biomaterial; elastomer; biocompatibility; degradation; poly(xylitol sebacate; xylitol
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Charles Stark Draper Laboratory
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/jbm.a.32733
