Insights into Alzheimer’s disease from single-cell genomic approaches
Name
Murdock_NN_10-24-22[62].pdf
Description
Accepted version
Size
1.41 MB
Format
Adobe PDF
Checksum (MD5)
c93a06b2a5f95a4efb28235fe9073bc2
Author(s)
Murdock, Mitchell H
Tsai, Li-Huei
Date Issued
February 2023
Journal
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Citation
Murdock, Mitchell H and Tsai, Li-Huei. 2023. "Insights into Alzheimer’s disease from single-cell genomic approaches." Nature Neuroscience, 26 (2).
Version
Author's final manuscript
Abstract
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling has shown that Alzheimer's dementia involves the complex interplay of virtually every major brain cell type. Here, we highlight cell-type-specific molecular perturbations in AD. We discuss how genomic information from single cells expands existing paradigms of AD pathogenesis and highlight new opportunities for therapeutic interventions.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/s41593-022-01222-2
