Precision mass measurements in solution reveal properties of single cells and bioparticles
Name
Olcum_IEDM_paper_final-manalis.pdf
Size
3.48 MB
Format
Adobe PDF
Checksum (MD5)
0505b2e6573c098d9540868b837168b4
Author(s)
Olcum, Selim A.
Cermak, Nathan
Manalis, Scott R
Date Issued
December 2015
Journal
2015 IEEE International Electron Devices Meeting (IEDM)
Publisher
Institute of Electrical and Electronics Engineers
Citation
Olcum, Selim, Nathan Cermak, and Scott R. Manalis. “Precision Mass Measurements in Solution Reveal Properties of Single Cells and Bioparticles.” 2015 IEEE International Electron Devices Meeting (IEDM) (December 2015).
Version
Author's final manuscript
Abstract
Precise characterization of biological materials ranging from single cells (~1-20 microns) to extracellular vesicles (20-200 nm) is of fundamental interest because of their biological and translational value. Here we discuss the value of precision mass measurements in solution for informing various physical and biological parameters, such as mass accumulation rate, longitudinal cell growth or cell density. We introduce how the limits of the single-particle mass measurements can be pushed down to nano-scale dimensions enabling the resolution of extracellular vesicles and viruses in solution. We believe with future advancements on the precision and throughput of this approach, the capability of analyzing biologically relevant particles in solution will have broad biological and translational impact.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
Program in Media Arts and Sciences (Massachusetts Institute of Technology)
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1109/IEDM.2015.7409691
