Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy
Name
nihms940707.pdf
Description
Accepted version
Size
2.98 MB
Format
Adobe PDF
Checksum (MD5)
c9e9171118836077ac56d85df77aa136
Author(s)
Guimarães, Pedro P.G.
Gaglione, Stephanie
Sewastianik, Tomasz
Carrasco, Ruben D.
Langer, Robert S
Mitchell, Michael J.
Date Issued
January 2018
Journal
ACS Nano
Publisher
American Chemical Society (ACS)
Citation
Guimarães, Pedro P.G. et al., "Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy." ACS Nano 12, 2 (February 2018): 912–31 ©2018 Authors
Version
Author's final manuscript
Abstract
The immune cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has received significant attention as a cancer therapeutic due to its ability to selectively trigger cancer cell apoptosis without causing toxicity in vivo. While TRAIL has demonstrated significant promise in preclinical studies in mice as a cancer therapeutic, challenges including poor circulation half-life, inefficient delivery to target sites, and TRAIL resistance have hindered clinical translation. Recent advances in drug delivery, materials science, and nanotechnology are now being exploited to develop next-generation nanoparticle platforms to overcome barriers to TRAIL therapeutic delivery. Here, we review the design and implementation of nanoparticles to enhance TRAIL-based cancer therapy. The platforms we discuss are diverse in their approaches to the delivery problem and provide valuable insight into guiding the design of future nanoparticle-based TRAIL cancer therapeutics to potentially enable future translation into the clinic. ©2018 American Chemical Society.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ACSNANO.7B05876
