Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells
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Tunable nanostructured.pdf
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Author(s)
Aceto, Nicola
Lim, Eugene J.
Sullivan, James P.
Jensen, Anne E.
Zeinali, Mahnaz
Martel, Joseph M.
Aranyosi, Alexander J.
Li, Wei
Castleberry, Steven
Bardia, Aditya
Date Issued
January 2015
Journal
Advanced Materials
Publisher
Wiley Blackwell
Citation
Reategui, Eduardo, Nicola Aceto, Eugene J. Lim, James P. Sullivan, Anne E. Jensen, Mahnaz Zeinali, Joseph M. Martel, et al. “Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells.” Advanced Materials 27, no. 9 (January 15, 2015): 1593–1599.
Version
Author's final manuscript
Abstract
A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adma.201404677
