Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity
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Orr-Weaver_Polyploidization.pdf
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1.53 MB
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Author(s)
Unhavaithaya, Yingdee
Orr-Weaver, Terry
Date Issued
January 2012
Journal
Genes & Development
Publisher
Cold Spring Harbor Laboratory Press
Citation
Unhavaithaya, Y., and T. L. Orr-Weaver. “Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity.” Genes & Development 26, no. 1 (January 3, 2012): 31-36. Copyright © 2012 by Cold Spring Harbor Laboratory Press
Version
Final published version
Abstract
Proper development requires coordination in growth of the cell types composing an organ. Many plant and animal cells are polyploid, but how these polyploid tissues contribute to organ growth is not well understood. We found the Drosophila melanogaster subperineurial glia (SPG) to be polyploid, and ploidy is coordinated with brain mass. Inhibition of SPG polyploidy caused rupture of the septate junctions necessary for the blood–brain barrier. Thus, the increased SPG cell size resulting from polyploidization is required to maintain the SPG envelope surrounding the growing brain. Polyploidization likely is a conserved strategy to coordinate tissue growth during organogenesis, with potential vertebrate examples.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Whitehead Institute for Biomedical Research
Terms of Use
Creative Commons Attribution-Non-Commercial 3.0 (CC-BY-NC)
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1101/gad.177436.111
