Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb
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Boyden_Independent control.pdf
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Author(s)
Fukunaga, Izumi
Herb, Jan T.
Kollo, Mihaly
Boyden, Edward Stuart
Schaefer, Andreas T.
Date Issued
July 2014
Journal
Nature Neuroscience
Publisher
Nature Publishing Group
Citation
Fukunaga, Izumi, Jan T Herb, Mihaly Kollo, Edward S Boyden, and Andreas T Schaefer. “Independent Control of Gamma and Theta Activity by Distinct Interneuron Networks in the Olfactory Bulb.” Nat Neurosci 17, no. 9 (July 6, 2014): 1208–1216.
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Author's final manuscript
Abstract
Circuits in the brain possess the ability to orchestrate activities on different timescales, but the manner in which distinct circuits interact to sculpt diverse rhythms remains unresolved. The olfactory bulb is a classic example of a place in which slow theta and fast gamma rhythms coexist. Furthermore, inhibitory interneurons that are generally implicated in rhythm generation are segregated into distinct layers, neatly separating local and global motifs. We combined intracellular recordings in vivo with circuit-specific optogenetic interference to examine the contribution of inhibition to rhythmic activity in the mouse olfactory bulb. We found that the two inhibitory circuits controlled rhythms on distinct timescales: local, glomerular networks coordinated theta activity, regulating baseline and odor-evoked inhibition, whereas granule cells orchestrated gamma synchrony and spike timing. Notably, granule cells did not contribute to baseline rhythms or sniff-coupled odor-evoked inhibition. Thus, activities on theta and gamma timescales are controlled by separate, dissociable inhibitory networks in the olfactory bulb.
MIT Department
Massachusetts Institute of Technology. Synthetic Neurobiology Group
Massachusetts Institute of Technology. Media Laboratory
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DOI of Published Version
https://doi.org/10.1038/nn.3760
