RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo
Name
nihms-1521943.pdf
Description
Accepted version
Size
2.51 MB
Format
Adobe PDF
Checksum (MD5)
96bedf3f15f93986884277d51e489402
Author(s)
Wesselhoeft, R Alexander
Kowalski, Piotr S
Parker-Hale, Frances C
Huang, Yuxuan
Bisaria, Namita
Anderson, Daniel G
Date Issued
2019
Journal
Molecular Cell
Publisher
Elsevier BV
Version
Author's final manuscript
Abstract
© 2019 Elsevier Inc. Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Political Science
Whitehead Institute for Biomedical Research
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1016/J.MOLCEL.2019.02.015
https://doi.org/10.1016/J.MOLCEL.2019.02.015
