Metastasis: tumor cells becoming MENAcing
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Gertler_Metastasis tumor.pdf
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982.45 KB
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Author(s)
Gertler, Frank
Condeelis, John
Date Issued
November 2010
Journal
Trends in Cell Biology
Publisher
Elsevier
Citation
Gertler, Frank, and John Condeelis. “Metastasis: Tumor Cells Becoming MENAcing.” Trends in Cell Biology 21, no. 2 (February 2011): 81–90.
Version
Author's final manuscript
Abstract
During breast cancer metastasis cells emigrate from the primary tumor to the bloodstream, and this carries them to distant sites where they infiltrate and sometimes form metastases within target organs. These cells must penetrate the dense extracellular matrix comprising the basement membrane of the mammary duct/acinus and migrate toward blood and lymphatic vessels, processes that mammary tumor cells execute primarily using epidermal growth factor (EGF)-dependent protrusive and migratory activity. Here, we focus on how the actin regulatory protein Mena affects EGF-elicited movement, invasion and metastasis. Recent findings indicate that, in invasive migratory tumor cells, Mena isoforms that endow heightened sensitivity to EGF and increased protrusive and migratory abilities are upregulated, whereas other isoforms are selectively downregulated. This change in Mena isoform expression enables tumor cells to invade in response to otherwise benign EGF stimulus levels and could offer an opportunity to identify metastatic risk in patients.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-NoDerivatives
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DOI of Published Version
https://doi.org/10.1016/j.tcb.2010.10.001
