Dysfunction of Rapid Neural Adaptation in Dyslexia
Name
nihms839921.pdf
Description
Accepted version
Size
2.17 MB
Format
Adobe PDF
Checksum (MD5)
3d8aa52192523c07285230dbdc7cec4e
Author(s)
Perrachione, Tyler Kent
Del Tufo, Stephanie Nicole
Winter, Rebecca
Murtagh, Jack
Cyr, Abigail B.
Chang, Patricia
Halverson, Kelly
Ghosh, Satrajit S
Christodoulou, Joanna
Gabrieli, John D. E.
Date Issued
December 2016
Journal
Neuron
Publisher
Elsevier BV
Citation
Perrachione, Tyler K. et al. "Dysfunction of Rapid Neural Adaptation in Dyslexia." Neuron 92, 6 (December 2016): P1383-1397 © 2016 Elsevier Inc
Version
Author's final manuscript
Abstract
Identification of specific neurophysiological dysfunctions resulting in selective reading difficulty (dyslexia) has remained elusive. In addition to impaired reading development, individuals with dyslexia frequently exhibit behavioral deficits in perceptual adaptation. Here, we assessed neurophysiological adaptation to stimulus repetition in adults and children with dyslexia for a wide variety of stimuli, spoken words, written words, visual objects, and faces. For every stimulus type, individuals with dyslexia exhibited significantly diminished neural adaptation compared to controls in stimulus-specific cortical areas. Better reading skills in adults and children with dyslexia were associated with greater repetition-induced neural adaptation. These results highlight a dysfunction of rapid neural adaptation as a core neurophysiological difference in dyslexia that may underlie impaired reading development. Reduced neurophysiological adaptation may relate to prior reports of reduced behavioral adaptation in dyslexia and may reveal a difference in brain functions that ultimately results in a specific reading impairment.
MIT Department
McGovern Institute for Brain Research at MIT
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.neuron.2016.11.020
