Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes
Name
Advanced Science - 2021 - Goswami - Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for.pdf
Size
9.45 MB
Format
Adobe PDF
Checksum (MD5)
8e0cb41e01b97f5794e139cd2bdb2ee4
Author(s)
Goswami, Debkalpa
Domingo-Lopez, Daniel A
Ward, Niamh A
Millman, Jeffrey R
Duffy, Garry P
Dolan, Eimear B
Roche, Ellen
Date Issued
2021
Journal
Advanced Science
Publisher
Wiley
Citation
Goswami, Debkalpa, Domingo-Lopez, Daniel A, Ward, Niamh A, Millman, Jeffrey R, Duffy, Garry P et al. 2021. "Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes." Advanced Science, 8 (16).
Version
Final published version
Abstract
Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long-term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is to utilize an islet macroencapsulation device, where islets are incorporated into a selectively permeable membrane that can protect the transplanted cells from acute host response, whilst enabling delivery of insulin. These macroencapsulation systems have to meet a number of stringent and challenging design criteria in order to achieve the ultimate goal of reversing T1D. In this progress report, the design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets (SC-islets), highlighting distinct design parameters. Additionally, a perspective on the future for macroencapsulation systems is given, and how incorporating continuous sensing and closed-loop feedback can be transformative in advancing toward an autonomous biohybrid artificial pancreas.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution NonCommercial License 4.0
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/ADVS.202100820
