Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery
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Anderson_Lipid-modified.pdf
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1.38 MB
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Author(s)
Zhang, Yunlong
Heller, Daniel A.
Dong, Yizhou
Chen, Delai
Gu, Zhen
Joseph, Brian J.
Wallas, Jasmine
Anderson, Daniel Griffith
Pelet, Jeisa
Date Issued
September 2013
Journal
Advanced Materials
Publisher
Wiley-VCH Verlag GmbH & Co.
Citation
Zhang, Yunlong, Jeisa M. Pelet, Daniel A. Heller, Yizhou Dong, Delai Chen, Zhen Gu, Brian J. Joseph, Jasmine Wallas, and Daniel G. Anderson. “Lipid-Modified Aminoglycoside Derivatives for In Vivo siRNA Delivery.” Advanced Materials 25, no. 33 (June 27, 2013): 4641–4645.
Version
Author's final manuscript
Abstract
Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/adma.201301917
