Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment
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Tsai_Activity-Dependent P25.pdf
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Author(s)
Seo, Jinsoo
Zhou, Ying
Rudenko, Andrii
Cho, Sukhee
Ota, Kristie
Park, Christine
Patzke, Holger
Madabhushi, Ram
Pan, Ling
Guan, Ji-Song
Date Issued
April 2014
Journal
Cell
Publisher
Elsevier
Citation
Seo, Jinsoo, Paola Giusti-Rodríguez, Ying Zhou, Andrii Rudenko, Sukhee Cho, Kristie T. Ota, Christine Park, et al. “Activity-Dependent P25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment.” Cell 157, no. 2 (April 2014): 486–498.
Version
Author's final manuscript
Abstract
Cyclin-dependent kinase 5 regulates numerous neuronal functions with its activator, p35. Under neurotoxic conditions, p35 undergoes proteolytic cleavage to liberate p25, which has been implicated in various neurodegenerative diseases. Here, we show that p25 is generated following neuronal activity under physiological conditions in a GluN2B- and CaMKIIα-dependent manner. Moreover, we developed a knockin mouse model in which endogenous p35 is replaced with a calpain-resistant mutant p35 (Δp35KI) to prevent p25 generation. The Δp35KI mice exhibit impaired long-term depression and defective memory extinction, likely mediated through persistent GluA1 phosphorylation at Ser845. Finally, crossing the Δp35KI mice with the 5XFAD mouse model of Alzheimer’s disease (AD) resulted in an amelioration of β-amyloid (Aβ)-induced synaptic depression and cognitive impairment. Together, these results reveal a physiological role of p25 production in synaptic plasticity and memory and provide new insights into the function of p25 in Aβ-associated neurotoxicity and AD-like pathology.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.cell.2014.01.065
