Migration alters oscillatory dynamics and promotes survival in connected bacterial populations
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s41467-018-07703-y.pdf
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1.63 MB
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Checksum (MD5)
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Author(s)
Ranjan, Tanvi
Gokhale, Shreyas Shashank
Conwill, Arolyn Macdonald
Gore, Jeff
Date Issued
December 2018
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Gokhale, Shreyas et al. “Migration Alters Oscillatory Dynamics and Promotes Survival in Connected Bacterial Populations.” Nature Communications 9, 1 (December 2018): 5273 © 2018 The Author(s)
Version
Final published version
Abstract
Migration influences population dynamics on networks, thereby playing a vital role in scenarios ranging from species extinction to epidemic propagation. While low migration rates prevent local populations from becoming extinct, high migration rates enhance the risk of global extinction by synchronizing the dynamics of connected populations. Here, we investigate this trade-off using two mutualistic strains of E. coli that exhibit population oscillations when co-cultured. In experiments, as well as in simulations using a mechanistic model, we observe that high migration rates lead to synchronization whereas intermediate migration rates perturb the oscillations and change their period. Further, our simulations predict, and experiments show, that connected populations subjected to more challenging antibiotic concentrations have the highest probability of survival at intermediate migration rates. Finally, we identify altered population dynamics, rather than recolonization, as the primary cause of extended survival.
MIT Department
Massachusetts Institute of Technology. Department of Physics
Terms of Use
Creative Commons Attribution 4.0 International license
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DOI of Published Version
https://doi.org/10.1038/s41467-018-07703-y
