Development and challenges of antimicrobial peptides for therapeutic applications
Name
antibiotics-09-00024.pdf
Size
2.02 MB
Format
Adobe PDF
Checksum (MD5)
d0815bde1d58a862f6f647f773c23156
Author(s)
Chen, Charles H.
Lu, Timothy K
Date Issued
January 13, 2020
Journal
Antibiotics
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Chen, Charles H., and Timothy K. Lu, "Development and challenges of antimicrobial peptides for therapeutic applications." Antibiotics 9, 1 (Jan. 2020): no. 24 doi 10.3390/antibiotics9010024 ©2020 Author(s)
Version
Final published version
Abstract
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have been approved by the U.S. Food and Drug Administration (FDA). Now commercialized, these seven peptides have mostly been utilized for topical medications, though some have been injected into the body to treat severe bacterial infections. To understand the translational potential for AMPs, we analyzed FDA-approved drugs in the FDA drug database. We examined their physicochemical properties, secondary structures, and mechanisms of action, and compared them with the peptides in the AMP database. All FDA-approved AMPs were discovered in Gram-positive soil bacteria, and 98% of known AMPs also come from natural sources (skin secretions of frogs and toxins from different species). However, AMPs can have undesirable properties as drugs, including instability and toxicity. Thus, the design and construction of effective AMPs require an understanding of the mechanisms of known peptides and their effects on the human body. This review provides an overview to guide the development of AMPs that can potentially be used as antimicrobial drugs. Keywords: antimicrobial peptides; antibiotics; antibiotic resistance; rational protein design; peptide therapeutics; FDA-approved peptides
MIT Department
Massachusetts Institute of Technology. Research Laboratory of Electronics
Broad Institute of MIT and Harvard
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.3390/antibiotics9010024
