Molecular signatures of neural connectivity in the olfactory cortex
Name
Molecular signatures.pdf
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2.25 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Diodato, Assunta
Ruinart de Brimont, Marion
Derian, Nicolas
Perrin, Sandrine
Pouch, Juliette
Klatzmann, David
Garel, Sonia
Fleischmann, Alexander
Yim, Yeong Shin
Choi, Bohyun Gloria
Date Issued
July 2016
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Diodato, Assunta et al. “Molecular Signatures of Neural Connectivity in the Olfactory Cortex.” Nature Communications 7 (2016): 12238.
Version
Final published version
Abstract
The ability to target subclasses of neurons with defined connectivity is crucial for uncovering neural circuit functions. The olfactory (piriform) cortex is thought to generate odour percepts and memories, and odour information encoded in piriform is routed to target brain areas involved in multimodal sensory integration, cognition and motor control. However, it remains unknown if piriform outputs are spatially organized, and if distinct output channels are delineated by different gene expression patterns. Here we identify genes selectively expressed in different layers of the piriform cortex. Neural tracing experiments reveal that these layer-specific piriform genes mark different subclasses of neurons, which project to distinct target areas. Interestingly, these molecular signatures of connectivity are maintained in reeler mutant mice, in which neural positioning is scrambled. These results reveal that a predictive link between a neuron’s molecular identity and connectivity in this cortical circuit is determined independent of its spatial position.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/ncomms12238
