Ex vivo imaging of human thyroid pathology using integrated optical tomography and optical coherence microscopy
Name
Zhou-2010-Ex vivo imaging of h.pdf
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2.39 MB
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Author(s)
Fujimoto, James G.
Zhou, Chao
Tsai, Tsung-Han
Aguirre, Aaron Dominic
Wang, Yihong
Cohen, David W.
Connolly, James L.
Date Issued
February 2010
Journal
Journal of Biomedical Optics
Publisher
Society of Photo-optical Instrumentation Engineers
Citation
Zhou, Chao et al. “Ex vivo imaging of human thyroid pathology using integrated optical coherence tomography and optical coherence microscopy.” Journal of Biomedical Optics 15.1 (2010): 016001-9. ©2010 Society of Photo-Optical Instrumentation Engineers.
Version
Final published version
Abstract
We evaluate the feasibility of optical coherence tomography (OCT) and optical coherence microscopy (OCM) for imaging of benign and malignant thyroid lesions ex vivo using intrinsic optical contrast. 34 thyroid gland specimens are imaged from 17 patients, covering a spectrum of pathology ranging from normal thyroid to benign disease/neoplasms (multinodular colloid goiter, Hashimoto's thyroiditis, and follicular adenoma) and malignant thyroid tumors (papillary carcinoma and medullary carcinoma). Imaging is performed using an integrated OCT and OCM system, with <4 [micrometer] axial resolution (OCT and OCM), and 14 [micrometer] (OCT) and <2 [micrometer](OCM) transverse resolution. The system allows seamless switching between low and high magnifications in a way similar to traditional microscopy. Good correspondence is observed between optical images and histological sections. Characteristic features that suggest malignant lesions, such as complex papillary architecture, microfollicules, psammomatous calcifications, or replacement of normal follicular architecture with sheets/nests of tumor cells, can be identified from OCT and OCM images and are clearly differentiable from normal or benign thyroid tissues. With further development of needle-based imaging probes, OCT and OCM could be promising techniques to use for the screening of thyroid nodules and to improve the diagnostic specificity of fine needle aspiration evaluation.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1117/1.3306696
