Not All T Cell Synapses Are Built the Same Way
Name
1-s2.0-S1471490619301978-main.pdf
Description
Published version
Size
641.57 KB
Format
Adobe PDF
Checksum (MD5)
17d71e24577efb525ef656cf890edf6b
Author(s)
Kumari, Sudha
Colin-York, Huw
Irvine, Darrell J
Fritzsche, Marco
Date Issued
October 2019
Journal
Trends in Immunology
Publisher
Cell Press/Elsevier BV
Citation
Kumari, Sudha et al. "Not All T Cell Synapses Are Built the Same Way." Trends in Immunology 40, 11 (November 2019): P977-980 © 2019 The Author(s)
Version
Final published version
Abstract
T cells comprise functionally diverse subtypes. Although activated via a conserved scheme of antigen recognition by their T cell receptor, they elicit heterogeneous activation and effector responses. Such functional diversity has been appreciated in gene expression studies, functional assays, and disease models. Yet, our understanding of the principles underlying T cell subtype-specific activation and antigen recognition in the immunological synapse remains limited. This is primarily due to difficulties in primary T cell visualization at high spatiotemporal resolution and the adoption of tractable transformed T cell systems for cell biological experiments that may not correctly represent primary T cell constitutional diversity. Here, we discuss recent findings regarding the architectural and dynamic diversity of the immunological synapse and state-of-the-art methodologies that can be utilized to provide clues on how biological and biophysical differences in synaptic make-up could govern functional divergences in T cell subtypes.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.it.2019.09.009
