In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy
Name
c8an00913a.pdf
Size
1.11 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Jonas, Oliver
Singh, Surya P.
Lammers, Alex
Dasari, Ramachandra R.
So, Peter T. C.
Nguyen, Freddy T.
Langer, Robert S
Kang, Jeon Woong
Cima, Michael J.
Date Issued
July 2018
Journal
The Analyst
Publisher
Royal Society of Chemistry
Citation
Jonas, Oliver, et al. “In Vivo Detection of Drug-Induced Apoptosis in Tumors Using Raman Spectroscopy.” The Analyst, 2018. © 2018 The Royal Society of Chemistry
Version
Final published version
Abstract
We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Laser Biomedical Research Center
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial 3.0 Unported
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/c8an00913a
