Cognitive training changes hippocampal function in mild cognitive impairment: A pilot study
Name
Gabrieli-Cognitive Training Changes Hippocampal.pdf
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Author(s)
Rosen, Allyson C.
Sugiura, Lisa
Kramer, Joel H.
Gabrieli, Susan
Gabrieli, John D. E.
Date Issued
August 2011
Journal
Journal of Alzheimer's Disease
Publisher
IOS Press
Citation
Rosen, Allyson C. et al. "Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study." Journal of Alzheimer’s Disease 2011 ; 26(Suppl 3): 349–357.
Version
Author's final manuscript
Abstract
A randomized pilot experiment examined the neural substrates of response to cognitive training in
participants with mild cognitive impairment (MCI). Participants performed exercises previously
demonstrated to improve verbal memory and an active control group performed other computer
activities. An auditory-verbal fMRI task was conducted before and after the two-month training
program. Verbal memory scores improved significantly and left hippocampal activation increased
significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain
sufficient neuroplasticity to benefit from cognitive training.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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DOI of Published Version
http://iospress.metapress.com/content/x083w76454777605/fulltext.pdf
