Chiral Supraparticles for Controllable Nanomedicine
Name
nihms-1058565.pdf
Description
Accepted version
Size
2.63 MB
Format
Adobe PDF
Checksum (MD5)
87c61dd2b9f57750b9564c95514a5f68
Author(s)
Yeom, Jihyeon
Guimaraes, Pedro PG
Ahn, Hyo Min
Jung, Bo-Kyeong
Hu, Quanyin
McHugh, Kevin
Mitchell, Michael J
Yun, Chae-Ok
Langer, Robert
Jaklenec, Ana
Date Issued
2020
Journal
Advanced Materials
Publisher
Wiley
Version
Author's final manuscript
Abstract
Chirality is ubiquitous in nature and hard-wired into every biological system. Despite the prevalence of chirality in biological systems, controlling biomaterial chirality to influence interactions with cells has only recently been explored. Chiral-engineered supraparticles (SPs) that interact differentially with cells and proteins depending on their handedness are presented. SPs coordinated with d-chirality demonstrate greater than threefold enhanced cell membrane penetration in breast, cervical, and multiple myeloma cancer cells. Quartz crystal microbalance with dissipation and isothermal titration calorimetry measurements reveal the mechanism of these chiral-specific interactions. Thermodynamically, d-SPs show more stable adhesion to lipid layers composed of phospholipids and cholesterol compared to l-SPs. In vivo, d-SPs exhibit superior stability and longer biological half-lives likely due to opposite chirality and thus protection from endogenous proteins including proteases. This work shows that incorporating d-chirality into nanosystems enhances uptake by cancer cells and prolonged in vivo stability in circulation, providing support for the importance of chirality in biomaterials. Thus, chiral nanosystems may have the potential to provide a new level of control for drug delivery systems, tumor detection markers, biosensors, and other biomaterial-based devices.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/ADMA.201903878
