Estimation of changes in instantaneous aortic blood flow by the analysis of arterial blood pressure
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2012-Arai-japplphysiol.01565.2011.pdf
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Author(s)
Marini, Robert P.
Arai, Tatsuya
Lee, Kichang
Cohen, Richard J.
Date Issued
March 2012
Journal
Journal of Applied Physiology
Publisher
American Physiological Society
Citation
Arai, T., K. Lee, R. P. Marini, and R. J. Cohen. Estimation of Changes in Instantaneous Aortic Blood Flow by the Analysis of Arterial Blood Pressure. Journal of Applied Physiology 112, no. 11 (June 1, 2012): 1832-1838.
Version
Author's final manuscript
Abstract
The purpose of this study was to introduce and validate a new algorithm to estimate instantaneous aortic blood flow (ABF) by mathematical analysis of arterial blood pressure (ABP) waveforms. The algorithm is based on an autoregressive with exogenous input (ARX) model. We applied this algorithm to diastolic ABP waveforms to estimate the autoregressive model coefficients by requiring the estimated diastolic flow to be zero. The algorithm incorporating the coefficients was then applied to the entire ABP signal to estimate ABF. The algorithm was applied to six Yorkshire swine data sets over a wide range of physiological conditions for validation. Quantitative measures of waveform shape (standard deviation, skewness, and kurtosis), as well as stroke volume and cardiac output from the estimated ABF, were computed. Values of these measures were compared with those obtained from ABF waveforms recorded using a Transonic aortic flow probe placed around the aortic root. The estimation errors were compared with those obtained using a windkessel model. The ARX model algorithm achieved significantly lower errors in the waveform measures, stroke volume, and cardiac output than those obtained using the windkessel model (P < 0.05).
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Aerospace Biomedical and Life Support Engineering
Massachusetts Institute of Technology. Division of Comparative Medicine
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1152/japplphysiol.01565.2011
