Context is everything: aneuploidy in cancer
Author(s)
Ben-David, Uri
Amon, Angelika B
Date Issued
September 2019
Journal
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Citation
Ben-David, Uri and Angelika Amon, "Context is everything: aneuploidy in cancer." Nature Reviews Genetics 21, 1 (January 2020): p. 44–62 doi. 10.1038/s41576-019-0171-x ©2019 Authors
Version
Author's final manuscript
Abstract
Cancer is driven by multiple types of genetic alterations, which range in size from point mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome instability, the process that gives rise to aneuploidy, can promote tumorigenesis by increasing genetic heterogeneity and promoting tumour evolution. However, much less is known about how aneuploidy itself contributes to tumour formation and progression. Unlike some pan-cancer oncogenes and tumour suppressor genes that drive transformation in virtually all cell types and cellular contexts, aneuploidy is not a universal promoter of tumorigenesis. Instead, recent studies suggest that aneuploidy is a context-dependent, cancer-type-specific oncogenic event that may have clinical relevance as a prognostic marker and as a potential therapeutic target. ©2019, Springer Nature Limited.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1038/S41576-019-0171-X
