Application of microtechnologies for the vascularization of engineered tissues
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2045-824X-3-24.pdf
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635.24 KB
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Adobe PDF
Checksum (MD5)
06a9a6bfb0ad45332baac33ce6892797
Author(s)
Gauvin, Robert
Guillemette, Maxime D.
Khademhosseini, Ali
Dokmeci, Mehmet R.
Date Issued
October 2011
Journal
Vascular Cell
Publisher
BioMed Central Ltd
Citation
Gauvin, Robert et al. “Application of Microtechnologies for the Vascularization of Engineered Tissues.” Vascular Cell 3.1 (2011): 24.
Version
Final published version
Abstract
Recent advances in medicine and healthcare allow people to live longer, increasing the need for the number of organ transplants. However, the number of organ donors has not been able to meet the demand, resulting in an organ shortage. The field of tissue engineering has emerged to produce organs to overcome this limitation. While tissue engineering of connective tissues such as skin and blood vessels have currently reached clinical studies, more complex organs are still far away from commercial availability due to pending challenges with in vitro engineering of 3D tissues. One of the major limitations of engineering large tissue structures is cell death resulting from the inability of nutrients to diffuse across large distances inside a scaffold. This task, carried out by the vasculature inside the body, has largely been described as one of the foremost important challenges in engineering 3D tissues since it remains one of the key steps for both in vitro production of tissue engineered construct and the in vivo integration of a transplanted tissue. This short review highlights the important challenges for vascularization and control of the microcirculatory system within engineered tissues, with particular emphasis on the use of microfabrication approaches.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/2045-824X-3-24
