Collagen and hyaluronic acid interpenetrating polymer networks for tissue engineering
Name
319172522-MIT.pdf
Description
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Author(s)
Brigham, Mark D
Advisor(s)
Ali Khademhosseini and Utkan Demirci.
Alternative Title
Collagen and hyaluronic acid IPNs for tissue engineering
Date Issued
2007
Publisher
Massachusetts Institute of Technology
Abstract
Interpenetrating Polymer Networks (IPNs) represent a strategy for combining the properties of several polymeric materials into a single network. In this thesis, collagen and methacrylated hyaluronic acid are combined in IPNs to produce a range of new biocompatible. The fabrication method allows for control of compressive strength of the IPN hydrogels. The materials are confirmed to be homogeneous at microscopic scales with fluorescent techniques. The IPNs are used for cell encapsulation and have the potential to be used for surface cell culture. The mechanical properties can be adjusted to match those of cardiac tissue. Thus, when combined with the properties of biocompatibility, viable cell encapsulation, and cell culture, the collagenMeHA IPN hydrogels represent a powerful new material for tissue engineering applications.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.
Includes bibliographical references (leaves 68-70).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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