Evaluation of nanoparticles-based thermotherapy for cancer
Name
228417099-MIT.pdf
Description
Full printable version
Size
4.38 MB
Format
Adobe PDF
Checksum (MD5)
5308ce97073af2e4558c8813f1b339c0
Author(s)
Wiryaatmadja, Edwina
Advisor(s)
Caroline Anne Ross.
Date Issued
2007
Publisher
Massachusetts Institute of Technology
Abstract
Under alternating magnetic field, superparamagnetic iron oxide nanoparticles can be used to generate heat for the treatment of cancer. With suitable coating, these nanoparticles are biocompatible, stable in solution, and absorbed by tumor cells in good contrast. The mechanism of heating is mainly due to Neel relaxation process and a quantity called specific loss power (SLP) / specific absorption rate (SAR) is used to describe the heating effect. Past clinical studies have shown minimum side effects and proven the success of the new thermotherapy as a treatment modality in conjunction with chemo- or radiotherapy. Studies are in progress to improve the nanoparticles' heating power to enable treatment of small tumors and metastases, thermoablation as a monotherapy, and to achieve tumor-specific thermotherapy with the aid of tumor-finding molecules. This paper evaluates the novel technology that is magnetic nanoparticles-based thermotherapy and explores its commercialization potential. It explains the medical need driving the innovation, examines the technology in comparison with existing cancer therapies, identifies the strategic position the technology has in the present state of market for cancer therapies, and explores opportunities and Challenges in the introduction of the new therapy into the U.S. market.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2007.
Includes bibliographical references (p. 83-88).
Subjects
Materials Science and Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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