miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain
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Saeij_Mir-146a.pdf
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Author(s)
Cannella, Dominique
Brenier-Pinchart, Marie-Pierre
Braun, Laurence
van Rooyen, Jason M.
Bougdour, Alexandre
Bastien, Olivier
Behnke, Michael S.
Curt, Rose-Laurence
Sibley, L. David
Hakimi, Mohamed-Ali
Date Issued
February 2014
Journal
Cell Reports
Publisher
Elsevier
Citation
Cannella, Dominique, Marie-Pierre Brenier-Pinchart, Laurence Braun, Jason M. van Rooyen, Alexandre Bougdour, Olivier Bastien, Michael S. Behnke, et al. “miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain.” Cell Reports 6, no. 5 (March 2014): 928–937.
Version
Final published version
Abstract
microRNAs were recently found to be regulators of the host response to infection by apicomplexan parasites. In this study, we identified two immunomodulatory microRNAs, miR-146a and miR-155, that were coinduced in the brains of mice challenged with Toxoplasma in a strain-specific manner. These microRNAs define a characteristic fingerprint for infection by type II strains, which are the most prevalent cause of human toxoplasmosis in Europe and North America. Using forward genetics, we showed that strain-specific differences in miR-146a modulation were in part mediated by the rhoptry kinase, ROP16. Remarkably, we found that miR-146a deficiency led to better control of parasite burden in the gut and most likely of early parasite dissemination in the brain tissue, resulting in the long-term survival of mice.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
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DOI of Published Version
https://doi.org/10.1016/j.celrep.2014.02.002
