Bacteriophage-based synthetic biology for the study of infectious diseases
Name
Lu_Bacteriophage-based.pdf
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1.2 MB
Format
Adobe PDF
Checksum (MD5)
a74e476ee48941b3afcfc858372c1889
Author(s)
Citorik, Robert James
Mimee, Mark Kyle
Lu, Timothy K
Date Issued
June 2014
Journal
Current Opinion in Microbiology
Publisher
Elsevier
Citation
Citorik, Robert J, Mark Mimee, and Timothy K Lu. “Bacteriophage-Based Synthetic Biology for the Study of Infectious Diseases.” Current Opinion in Microbiology 19 (June 2014): 59–69.
Version
Final published version
Abstract
Since their discovery, bacteriophages have contributed enormously to our understanding of molecular biology as model systems. Furthermore, bacteriophages have provided many tools that have advanced the fields of genetic engineering and synthetic biology. Here, we discuss bacteriophage-based technologies and their application to the study of infectious diseases. New strategies for engineering genomes have the potential to accelerate the design of novel phages as therapies, diagnostics, and tools. Though almost a century has elapsed since their discovery, bacteriophages continue to have a major impact on modern biological sciences, especially with the growth of multidrug-resistant bacteria and interest in the microbiome.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Synthetic Biology Center
Terms of Use
Article is available under a Creative Commons license; see publisher's site for details.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.mib.2014.05.022
