G-quadruplex–forming promoter sequences enable transcriptional activation in response to oxidative stress
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Fedeles-2017-G-quadruplex-forming promoter seq.pdf
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Author(s)
Fedeles, Bogdan I
Date Issued
March 2017
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Fedeles, Bogdan I. “G-Quadruplex–forming Promoter Sequences Enable Transcriptional Activation in Response to Oxidative Stress.” Proceedings of the National Academy of Sciences 114, 11 (March 2017): 2788–2790 © 2017 National Academy of Sciences
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Final published version
Abstract
Oxidative DNA damage is an implacable consequence of aerobic metabolism and often exacerbated in inflammatory processes that use reactive oxygen species (ROS) both as signaling molecules and as chemical warfare against pathogens. An extensive body of work, recently reviewed in ref. 1, has highlighted the deleterious consequences of oxidative DNA damage, which involves oxidized nucleobases that, if left unrepaired, are either mutagenic or strong replication blockers. Most oxidative DNA damage is efficiently processed by DNA repair pathways, primarily base excision repair (BER), the molecular details of which are generally well understood (2). However, an emerging area of research posits that certain oxidative DNA lesions and their associated repair complexes are intermediates in a signaling transduction cascade that uses ROS as secondary messengers to ultimately effect transcriptional regulation (3⇓⇓⇓–7). In PNAS, Fleming et al. (8) reinforce these notions by describing a compelling mechanism by which 8-oxoguanine (OG), a canonical oxidative DNA damage product, when occurring in guanine-rich, G-quadruplex–forming promoter sequences, directly up-regulates transcription of the downstream gene.
MIT Department
Massachusetts Institute of Technology. Center for Environmental Health Sciences
Massachusetts Institute of Technology. Department of Biological Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1701244114
