Theory and application of neural and graphical models in early cancer diagnostics
Name
1020173762-MIT.pdf
Description
Full printable version
Size
9.87 MB
Format
Adobe PDF
Checksum (MD5)
c37ae73d6822aa4eafe34f34836b4cdb
Author(s)
Radhakrishnan, Adityanarayanan
Advisor(s)
Caroline Uhler.
Date Issued
2017
Publisher
Massachusetts Institute of Technology
Abstract
With the recent availability of large training datasets and graphics processing units (GPUs), we address challenges in the application of graphical models and neural networks to prediction sensitive areas such as healthcare. We begin by presenting our work in the context of learning graphical models from biological data. Namely, we present a combinatorial perspective of Markov Equivalence Classes (MECs), which defines the size of solution spaces when attempting to learn a graphical model from data. Through our analysis, we show that the size of these MECs can be exponential with respect to features of the graph (such as average degree). We then switch contexts to address the challenge of developing interpretable complex models. Namely, we present a variational-inference-motivated neural network, PatchNet, that provides visual interpretability, and we present the application of our network to the Describable Textures Dataset (DTD), the ISIC-ISBI Melanoma Classification Challenge, and cell nucleus data.
Description
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.
Cataloged from PDF version of thesis. "May 2017." Hand written on title page: "June 2017."
Includes bibliographical references (pages 69-72).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
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