AMPA receptor inhibition by synaptically released zinc
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Kalappa-2015-AMPA receptor inhibi.pdf
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1016.67 KB
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Checksum (MD5)
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Author(s)
Kalappa, Bopanna I.
Anderson, Charles T.
Tzounopoulos, Thanos
Goldberg, Jacob Michael
Lippard, Stephen J.
Date Issued
December 2015
Journal
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences (U.S.)
Citation
Kalappa, Bopanna I.; Anderson, Charles T.; Goldberg, Jacob M.; Lippard, Stephen J. and Tzounopoulos, Thanos. “AMPA Receptor Inhibition by Synaptically Released Zinc.” Proceedings of the National Academy of Sciences 112, 51 (December 2015): 15749–15754 © 2015 National Academy of Sciences
Version
Final published version
Abstract
Ionotropic glutamate AMPA receptors (AMPARs) play a fundamental role in normal function and plasticity of the brain, and they are also involved in many brain disorders. Despite the central role of AMPARs in neurobiology, the modulation of synaptic AMPA responses by endogenous modulators remains not well understood. Here, in three synapses found in two different brain areas, we provide the first evidence, to our knowledge, that endogenous zinc is coreleased with glutamate and modulates the strength of synaptic AMPAR responses. Because in many neocortical areas more than 50% of excitatory presynaptic terminals contain zinc within their glutamatergic vesicles, our findings establish zinc as a general neuromodulator that allows for fine-tuning and plasticity of glutamatergic fast synaptic transmission in the brain.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1073/pnas.1512296112
