Microneedle gastric retention for drug delivery
Name
1051458407-MIT.pdf
Description
Full printable version
Size
2.38 MB
Format
Adobe PDF
Checksum (MD5)
8e7763fd2f43cf73c67f76e0ad868a05
Author(s)
Dellal, David (David M.)
Advisor(s)
Robert Langer.
Date Issued
2018
Publisher
Massachusetts Institute of Technology
Abstract
Traditional drug delivery methods, such as injection and ingestion, are associated with many challenges, including patient needle-phobia and patient adherence to a medication regimen. Biologic molecules, in particular, must be injected due to degradation by enzymes in the GI tract. Previous scientists have developed a method with the potential to inject macromolecules in the GI tract using microneedles that can implant themselves in the stomach lining; however, they do not provide long-term drug delivery. To create a controlled release micro injection, I hypothesize that a hooked needle will latch onto the muscularis mucosae layer in the stomach and reside.upwards of a week to deliver drugs. A number of trials and simulations have been designed to test the efficacy of this retention mechanism. Coupled with work in the creation of new pharmaceutical formulations, these needles can be loaded with any drug to ensure uptake into the blood stream over the course of several days.
Description
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, June 2018.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 25-28).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
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