An ingestible self-orienting system for oral delivery of macromolecules
Name
nihms-1018265.pdf
Description
Accepted version
Size
1.15 MB
Format
Adobe PDF
Checksum (MD5)
9a5d1046b8dd340f6752c5eff69b8a2b
Author(s)
Abramson, Alex
Caffarel Salvador, Ester
Khang, Minsoo
Dellal, David
Silverstein, David
Gao, Yuan
Cleveland, Cody
Collins, Joy E
Tamang, Siddartha M
Hayward, Alison M
Date Issued
February 7, 2019
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Abramson, Alex et al. "An ingestible self-orienting system for oral delivery of macromolecules." Science 363 (2019): 611-615 © 2019 The Author(s)
Version
Author's final manuscript
Abstract
Biomacromolecules have transformed our capacity to effectively treat diseases; however, their rapid degradation and poor absorption in the gastrointestinal (GI) tract generally limit their administration to parenteral routes. An oral biologic delivery system must aid in both localization and permeation to achieve systemic drug uptake. Inspired by the leopard tortoise’s ability to passively reorient, we developed an ingestible self-orienting millimeter-scale applicator (SOMA) that autonomously positions itself to engage with GI tissue. It then deploys milliposts fabricated from active pharmaceutical ingredients directly through the gastric mucosa while avoiding perforation. We conducted in vivo studies in rats and swine that support the applicator’s safety and, using insulin as a model drug, demonstrated that the SOMA delivers active pharmaceutical ingredient plasma levels comparable to those achieved with subcutaneous millipost administration.
Subjects
Multidisciplinary
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Division of Comparative Medicine
Massachusetts Institute of Technology. Media Laboratory
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/science.aau2277
