Optical inhibition of motor nerve and muscle activity
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Anikeeva_Optical inhibition.pdf
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Author(s)
Liske, Holly
Towne, Chris
Anikeeva, Polina Olegovna
Zhao, Shengli
Feng, Guoping
Deisseroth, Karl
Delp, Scott
Date Issued
June 2013
Journal
Muscle & Nerve
Publisher
Wiley-VCH Verlag GmbH & Co.
Citation
Liske, Holly, Chris Towne, Polina Anikeeva, Shengli Zhao, Guoping Feng, Karl Deisseroth, and Scott Delp. “ Optical Inhibition of Motor Nerve and Muscle Activity in Vivo .” Muscle Nerve 47, no. 6 (April 30, 2013): 916–921.
Version
Author's final manuscript
Abstract
Introduction: There is no therapeutic approach that provides precise and rapidly reversible inhibition of motor nerve and muscle activity for treatment of spastic hypertonia. Methods: We used optogenetics to demonstrate precise and rapidly reversible light-mediated inhibition of motor nerve and muscle activity in vivo in transgenic Thy1::eNpHR2.0 mice. Results: We found optical inhibition of motor nerve and muscle activity to be effective at all muscle force amplitudes and determined that muscle activity can be modulated by changing light pulse duration and light power density. Conclusions: This demonstration of optical inhibition of motor nerves is an important advancement toward novel optogenetics-based therapies for spastic hypertonia.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Materials Science and Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/mus.23696
