The SUMO guards for SNAIL
Name
22432-317266-4-PB.pdf
Size
682.4 KB
Format
Adobe PDF
Checksum (MD5)
5b41bafc099e486284b98771725ddf44
Author(s)
Ye, Xin
Weinberg, Robert A
Date Issued
November 2017
Journal
Oncotarget
Publisher
Impact Journals, LLC
Citation
Ye, Xin, and Robert A. Weinberg. “The SUMO Guards for SNAIL.” Oncotarget 8, no. 58 (November 15, 2017).
Version
Final published version
Abstract
The cell-biological program termed epithelial-mesenchymal transition (EMT) plays a key role in adenocarcinoma progression, invasion, and metastasis. An EMT operating within carcinoma cells can be activated by a variety of paracrine signals arising in the tumor microenvironment. These EMT-inducing signals trigger profound transcription changes through activation of EMT-inducing transcription factors (EMT-TFs), leading to repression of genes associated with the epithelial differentiation program and activation of those associated with the mesenchymal program.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution 3.0 Unported license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.18632/ONCOTARGET.22432
